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Colorado Parks and Wildlife personnel’s work and expertise on this disease is recognized both nationally and internationally.​

CPW researchers and biologists have studied chronic wasting disease on numerous fronts - addressing wildlife health issues and assisting public health experts and scientists with their ongoing research. Some of the files are large and may take a minute or two to download.​​

These articles are posted with the publisher's permission. All rights are reserved. Do not reproduce.​

Featured Articles

What does the new CWD study mean for the average hunter?

Applying sufficient hunting pressure can help control the spread of chronic wasting disease (CWD) in mule deer, according to a study published this month by Colorado Parks and Wildlife in the Journal of Wildlife Diseases.

Read more about the study and the effect of deer licenses on CWD prevalence in Colorado deer herds on ColoradoOutdoorsMag.com.
 


​​The First Five ​(or More) Decades of Chronic Wasting Disease: Lessons for the Five Decades to Come​

by M. W. Miller & J. R. Fischer

Chronic wasting disease (CWD), an infectious prion disease of at leas​t five cervid species, has run the gamut from minor scientific curiosity to national crisis since the syndrome’s first recognition in the late 1960s. As of April 2016, CWD had been reported in captive and/or free-ranging cervids in the United States (24 states), Canada (three provinces), South Korea, and Norway.

For details, read the full article​. 

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Journa​​l: The EMBO Journal (European Molecular Biology Organization Journal) 
Published By: European Molecular Biolo​gy Organization
Web Site:  http://www.embo.org/
Article Name: Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease                                                                        
Article Authors: Raymond, G. J., A. Bossers, L. D. Raymond, K. I. O'Rourke, L. E. McHolland, P. K. Bryant III, M. W. Miller, E. S. Williams, M. Smits, and B. Caughey.
Article Citation: 2000. 19(17):4425-4430

 

Journal: Emerging Infectious Diseases
Published By: ​National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC)
Web Site: http://www.cdc.gov
Article
​Name:​		 Chronic wasting disease and potential transmission to humans                                                                                                                                                  
Article Authors: Belay, E. D., R. A. Maddox, E. S. Williams, M. W. Miller, P. Gambetti, and L. B. Schonberger
Article Citation: 2004. 10(6):977-984
 
Article
Name:		 Environmental sources of prion transmission in mule deer (98KB)
Article Authors: Miller, M. W., E. S. Williams, N T. Hobbs and L. L. Wolfe
Article Citation: 2004. 10(6):1003-1006

 

​​​​​​Journal: Journal of General Virology
Published By: Society for General Microbiology
Web Site:  http://www.microbiologysociety.org/​​
Article Name: Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)
Article Authors:

Sigurdson, C. J., E. S. Williams, M. W. Miller, T. R. Spraker, K. I. O'Rourke, and E. A. Hoover.

Article Citation: 1999. 80(10):2757-2764
 
Article Name: PrPCWD in the myenteric plexus,vagosympathetic trunk and endocrine glands of deer with chronic wasting disease
Article Authors: Sigurdson, C. J., T. R. Spraker, M. W. Miller, B. Oesch, and E. A. Hoover
Article Citation: 2001. 82(10):2327-2334
 
Article Name: PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer
Article Authors: Sigurdson, C. J., C. Barillas-Mury, M. W. Miller, B. Oesch, L. J. M. van Keulen, J. P. M. Langeveld, and E. A. Hoover
Article Citation: 2002. 83(10):2617-2628
 
Article Name: Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy
Article Authors: Wild, M. A., T. R. Spraker, C. J. Sigurdson, K. I. O'Rourke and M. W. Miller
Article Citation: 2002. 83(10):2629-2634

 

Journal: Journal of Veterinary Diagnostic Investigation
Published By: American Association of Veterinary Laboratory Diagnosticians
The following information is being provided with the permission of the American Assoc. of Veterinary Laboratory Diagnosticians
Article Name: Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle
Article Authors:

Hamir, A. N., R. C. Cutlip, J. M. Miller, E. S. Williams, M. J. Stack, M. W. Miller, K. I. O'Rourke, and M. J. Chaplin.

Article Citation: 2001. 13(1):91-96
 
Article Name: Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease
Article Authors: Spraker, T. R., K. I. O'Rourke, A. Balachandran, R. R. Zink, B. A. Cummings, M. W. Miller, and B. E. Powers.
Article Citation: 2002. 14(1):3-7
 
Article Name: Survey of cattle in northeast Colorado for evidence of chronic wasting disease: geographical and high-risk targeted sample (731KB)
Article Authors: Gould, D. H., J. L. Voss, M. W. Miller, A. M. Bachand, B. A. Cummings, and A. A. Frank.
Article Citation: 2003. 15(3):274-277
 
Article Name: Field validation and assessment of an enzyme linked  immunosorbent assay for detecting chronic wasting disease in mule deer (Odocoileus hemionus), white-tailed deer (Odocoileus virginianus), and Rocky Mountain Elk (Cervus elaphus nelsoni)
Article Authors: Hibler, C. P., K. L. Wilson, T. R. Spraker, M. W. Miller, R. R. Zink, L. L. DeBuse, E. Andersen, D. Schweitzer, J. A. Kennedy, L. A. Baeten, J. F. Smeltzer, M. D. Salman, and B. E. Powers.
Article Citation: 2003. 15(4):311-319
 
Article Name: Abundant PrPCWD in tonsil from mule deer with preclinical chronic wasting disease
Article Authors: O'Rourke, K. I., D. Zhuang, A. Lyda, G. Gomez, E. S. Williams, W. Tuo, and M. W. Miller.
Article Citation: 2003. 15(4):320-323

 

​​Journal: Journal of Virology
Published By: American Society for Microbiology
Web Site:  http://www.asm.org 
Article Name: Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle
Article Authors: Race, R. E., A. Raines, T. G. M. Baron, M. W. Miller, A. Jenny, and E. S. Williams
Article Citation: 2002. 76(23):12365-12368

 

​Journal: Journal of Wildlife Diseases
Published By: Wildlife Disease Association
Web Site:  http://www.wildlifedisease.org/
Article Name: Spongiform encephalopathy in free-ranging mule deer Odocoileus hemionus), white-tailed deer (Odocoileus virginianus), and Rocky Mountain Elk (Cervus elaphus nelsoni) in northcentral Colorado
Article Authors:

Spraker, T. R., M. W. Miller, E. S. Williams, D. M. Getzy, W. J. Adrian, G. G. Schoonveld, R. A. Spowart, K. I. O'Rourke, J. M. Miller, and P. A. Merz.

Article Citation: 1997. 33(1):1-6
 
Article Name: Epidemiology of chronic wasting disease in captive Rocky Mountain elk
Article Authors: Miller, M. W., M. A. Wild, and E. S. Williams.
Article Citation: 1998. 34(3):532-538
 
Article Name: Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming
Article Authors: Miller, M. W., E. S. Williams, C. W. McCarty, T. R. Spraker, T. J. Kreeger, C. T. Larsen, and E. T. Thorne.
Article Citation: 2000. 36(4):676-690
 
Article Name: Detection of bias in harvest-estimates chronic wasting disease prevalence in mule deer
Article Authors: Conner, M. M., C. W. McCarty, and M. W. Miller.
Article Citation: 2000. 36(4):691-699
 
Article Name: Immobilization of mule deer with thiafentanil (A-3080) or thiafentanil plus xylazine
Article Authors:

Wolfe, L. L., W. R. Lance, and M. W. Miller

Article Citation:

2004. 40(2):282-287

 
Article Name: Epidemiology of chronic wasting disease in captive white-tailed and mule deer
Article Authors:

Miller, M. W. and M. A. Wild

Article Citation:

2004. 40(2):330-327

 
Article Name:

Relative Vulnerability of Chronic Wasting Disease: Infected Mule Deer to Vehicle Collisi​​ons

Article Authors:

Krumm, Caroline E, M. M. Conner and M. W. Miller

Article Citation:

2005. 41(3):503-511

 

​​Journal: Journal of Wildlife Management
Published By: The Wildlife Society
Web Site:  http://www.wildlife.org/
Article Name: Chronic wasting disease in mule deer: disease dynamics and control                                                                                                                                                  
Article Authors:

Gross, J. E. and M. W. Miller

Article Citation: 2001. 65(2):205-215
 
Article Name: Chronic wasting disease of deer and elk: a review with recommendations for management
Article Authors: Williams, E. S., M. W. Miller, T. J. Kreeger, R. H. Kahn, and E. T. Thorne.
Article Citation: 2002. 66(3):551-563
 
Article Name: Evaluation of antemortem sampling to estimate chronic wasting disease prevalence in free-ranging mule-deer
Article Authors: Wolfe, L. L., M. M. Conner, T. H. Baker, V. J. Dreitz, K. P. Burnham, E. S. Williams, N. T. Hobbs, and M. W. Miller.
Article Citation: 2002. 66(3):564-573
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​Article Name: ​Feasibility of "test-and-cull" for managing chronic wasting disease in urban mule deer
​Article Authors ​Wolfe, L. L., M. W. Miller, and E. S. Williams
​Article Citation:​ ​2004. 32(2):500-505
​​
​Journal: Veterinary Pathology 
Published By: American College of Veterinary Pathologists
Web Site:  http://www.acvp.org
Article Name:​ Horizontal prion transmission in mule deer (482KB)​                                                                                                                                                     
Article Authors: ​Miller, M. W. and E. S. Williams
Article Citation: 2003 Sept.4. 425(6953):35-36

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​Journal: Veterinary Pathology 
Published By: American College of Veterinary Pathologists
Web Site:  http://www.acvp.org
Article Name:​ Comparis​on of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of captive mule deer
Article Authors: Spraker, T. R., R. R. Zink, B. A. Cummings, M. A. Wild, M. W. Miller, and K. I. O'Rourke.
Article Citation: 2002. 39(1):110-119

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