Prying into Prions: Investigating Chronic Wasting Disease is written for high-school biology and genetics courses. This six-lesson module is designed for approximately two weeks of classroom instruction.
Chronic wasting disease (CWD) is a fatal neurological disease found in deer, elk, and moose. The disease attacks the brains of infected animals, causing them to become emaciated, display abnormal behavior, lose coordination, and eventually—die. Like other transmissible spongiform encephalopathies (TSEs), CWD is a “prion” disease. (Prion is short for “proteinaceous infectious particle”.)
The prion protein exists in two forms. The normal form is found in many types of cells, including those in the central nervous system. The pathological prion form has the same chemical composition, but a different shape! There may be no better illustration of the idea that form dictates function—a central tenet of science and biology.